CINCINNATI, April 23, 2025 -- The Life Science division of Meridian Bioscience, Inc., a leading global manufacturer of diagnostics and life science raw materials, today announced the expansion of its contract services, enabling assay developers working with qPCR, isothermal amplification, or next-generation sequencing (NGS) technologies to achieve enhanced assay stability, lower limits of detection (LOD), and improved cost efficiencies through Meridian's advanced enzyme stabilization technologies.
With decades of enzyme development expertise, Meridian provides end-to-end reagent customization to support a broad range of molecular chemistries. Now, with expanded capabilities, the company empowers assay developers to seamlessly transition from traditional wet chemistry to ambient temperature-stable assay formats—without compromising performance.
Meridian's innovative stabilization solutions, including lyophilization (freeze-drying) and air-drying, are ideal for applications in infectious disease and oncology. These formats offer a range of advantages: improved enzyme stability, extended shelf life, elimination of cold-chain logistics, and reduced manufacturing complexity and costs.
In addition to operational efficiencies, ambient temperature-stable formats simplify assay workflows by removing the need to thaw and aliquot reagents—enabling faster implementation and greater ease of use.
The Power of Ambient Temperature-Stable Assays for qPCR, Isothermal Amplification, and NGS
Whether optimizing existing assays or developing new lyophilized, air-dryable, or liquid-stable formats, Meridian delivers tailored solutions that meet or exceed the evolving demands of the diagnostics industry. Leveraging proprietary glycerol-free enzyme technology and specialized buffer formulations, Meridian provides assay developers with unmatched flexibility, reliability, and performance.
Key benefits include:
- Enhanced Stability & Shelf Life: Meridian's expertise extends reagent stability, ensuring consistent performance even under challenging storage and transport conditions. This eliminates the reliance on cold storage, simplifying global distribution.
- No Loss of Performance: By leveraging Meridian's proven technologies and know-how, the integrity of the assay is preserved during the stabilization of the enzymatic system. No loss in sensitivity or performance is observed, directly addressing common concerns about enzyme modifications. This is especially critical for applications in infectious disease and oncology, where detecting low-abundance targets is essential.
- Cost Savings & Operational Efficiencies: By transitioning to ambient-temperature-stable reagents, developers can reduce cold-chain logistics costs, streamline inventory management, and simplify manufacturing while accelerating time to market for diagnostic assays.
- Comprehensive Support from Concept to Commercialization
- Meridian's comprehensive service model supports assay developers throughout every stage of the transition to ambient temperature-stable formats. Services include:
- Direct Access to Enzymology and Enzyme Stabilization Expertise: Collaborate with Meridian's scientists to optimize assay protocols, overcome technical challenges, and accelerate product development.
- Custom Formulation & Process Development: Meridian tailors reagent formulations to ensure optimal performance post-stabilization, accommodating unique assay requirements for qPCR, isothermal amplification, and NGS.
- Scalable Manufacturing & Supply Chain Support: Meridian's vertically integrated supply chain provides access to high-quality enzymes, buffers, and dNTPs, consolidating reagent sourcing and reducing reliance on multiple vendors.
Driving Innovation in qPCR, Isothermal Amplification, and NGS Assays
"We have seen a growing demand for reliable, ambient-temperature stable molecular assays," said Lourdes Weltzien, Ph.D., President - Life Science, Meridian Bioscience. "With our deep expertise in enzyme stabilization technologies, we enable assay developers to enhance stability, improve assay sensitivity, and reduce costs – all while maintaining high performance. Our customized services provide a seamless transition from wet chemistry to ambient temperature stable formats, unlocking new possibilities for molecular diagnostics."
Meridian's services are ideal for diagnostic assay manufacturers, Contract Development and Manufacturing Organizations (CDMOs), Contract Research Organizations (CROs), and pharmaceutical companies developing companion diagnostics (CDx).
To learn more about Meridian's stabilization services, visit www.meridianbioscience.com/stabilizationservices
About Meridian Bioscience, Inc.
Meridian is a fully integrated life science company that develops, manufactures, markets, and distributes a broad range of innovative diagnostic and life science products. Through discovery and development, we provide critical life science raw materials used in immunological and molecular tests for human, animal, plant, and environmental applications. Our solutions support diagnostic manufacturers, biotech companies, and research institutions in more than 70 countries worldwide. Meridian is headquartered in Cincinnati, Ohio.
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